RT Journal Article
T1 Evolving AIDS- and non-AIDS Mortality and Predictors in the PISCIS Cohort of People Living With HIV in Catalonia and the Balearic Islands (Spain), 1998-2020
A1 Nomah, Daniel K
A1 Jamarkattel, Suju
A1 Bruguera, Andreu
A1 Moreno-Fornés, Sergio
A1 Díaz, Yesika
A1 Alonso, Lucía
A1 Aceitón, Jordi
A1 Llibre, Josep M
A1 Domingo, Pere
A1 Saumoy, Maria
A1 Homar, Francisco
A1 Fanjul, Francisco
A1 Navarro, Jordi
A1 de la Mora, Lorena
A1 Knobel, Hernando
A1 Orti, Amat
A1 Martin-Iguacel, Raquel
A1 Miró, José M
A1 Casabona, Jordi
A1 Reyes-Urueña, Juliana
AB Effective antiretroviral therapy (ART) has substantially reduced acquired immunodeficiency syndrome (AIDS)-related deaths, shifting the focus to non-AIDS conditions in people living with human immunodeficiency virus (HIV) (PLWH). We examined mortality trends and predictors of AIDS- and non-AIDS mortality in the Population HIV Cohort from Catalonia and Balearic Islands (PISCIS) cohort of PLWH from 1998 to 2020.We used a modified Coding Causes of Death in HIV protocol, which has been widely adopted by various HIV cohorts to classify mortality causes. We applied standardized mortality rates (SMR) to compare with the general population and used competing risks models to determine AIDS-related and non-AIDS-related mortality predictors.Among 30 394 PLWH (81.5% male, median age at death 47.3), crude mortality was 14.2 per 1000 person-years. All-cause standardized mortality rates dropped from 9.6 (95% confidence interval [CI], 8.45-10.90) in 1998 through 2003 to 3.33 (95% CI, 3.14-3.53) in 2015 through 2020, P for trend = .0001. Major causes were AIDS, non-AIDS cancers, cardiovascular disease, AIDS-defining cancers, viral hepatitis, and nonhepatitis liver disease. Predictors for AIDS-related mortality included being aged ≥40 years, not being a man who have sex with men, history of AIDS-defining illnesses, CD4 < 200 cells/µL, ≥2 comorbidities, and nonreceipt of ART. Non-AIDS mortality increased with age, injection drug use, heterosexual men, socioeconomic deprivation, CD4 200 to 349 cells/µL, nonreceipt of ART, and comorbidities, but migrants had lower risk (adjusted hazard risk, 0.69 [95% CI, .57-.83]).Mortality rates among PLWH have significantly decreased over the past 2 decades, with a notable shift toward non-AIDS-related causes. Continuous monitoring and effective management of these non-AIDS conditions are essential to enhance overall health outcomes.
PB Oxford
SN 2328-8957
YR 2024
FD 2024-04
LK https://hdl.handle.net/20.500.13003/20290
UL https://hdl.handle.net/20.500.13003/20290
LA eng
NO Khoury N, Ángeles Martínez M, Nishi SK, Ángel Martínez-González M, Corella D, Castañer O, et al. Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population. Environ Int. 2024 Mar 15;186:108565.
DS Docusalut
RD 21 ago. 2026