RT Journal Article
T1 Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life
A1 Santos-García, Diego
A1 de Deus Fonticoba, Teresa
A1 Cores Bartolomé, Carlos
A1 Feal Painceiras, Maria J
A1 Íñiguez-Alvarado, Maria Cristina
A1 García Díaz, Iago
A1 Jesús, Silvia
A1 Buongiorno, Maria Teresa
A1 Planellas, Lluís
A1 Cosgaya, Marina
A1 García Caldentey, Juan
A1 Caballol, Nuria
A1 Legarda Ramírez, Inés
A1 Hernández Vara, Jorge
A1 Cabo-Lopez, Iria
A1 López Manzanares, Lydia
A1 Gonzalez Aramburu, Isabel
A1 Ávila Rivera, Maria A
A1 Gómez Mayordomo, Víctor
A1 Nogueira, Víctor
A1 Puente, Víctor
A1 Dotor, Julio
A1 Borrué, Carmen
A1 Solano Vila, Berta
A1 Alvarez Sauco, Maria
A1 Vela, Lydia
A1 Escalante, Sonia
A1 Cubo, Esther
A1 Carrillo Padilla, Francisco
A1 Martínez Castrillo, Juan C
A1 Sánchez Alonso, Pilar
A1 Alonso Losada, Maria G
A1 López Ariztegui, Nuria
A1 Gastón, Itziar
A1 Kulisevsky, Jaime
A1 Menéndez González, Manuel
A1 Seijo, Manuel
A1 Ruiz Martinez, Javier
A1 Valero, Caridad
A1 Kurtis, Mónica
A1 González Ardura, Jessica
A1 Alonso Redondo, Ruben
A1 Ordás, Carlos
A1 López Díaz, Luis M
A1 McAfee, Darrian
A1 Calopa, Matilde
A1 Carrillo, Fátima
A1 Escamilla Sevilla, Francisco
A1 Freire-Alvarez, Eric
A1 Gómez Esteban, Juan Carlos
A1 García Ramos, Rocío
A1 Luquín, María Rosario Isabel
A1 Martínez-Torres, Irene
A1 Sesar Ignacio, Ángel
A1 Martinez-Martin, Pablo
A1 Mir, Pablo
AB Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD).Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity.Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8).Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages.Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.
PB IOS Press
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.13003/19925
UL https://hdl.handle.net/20.500.13003/19925
LA eng
NO Santos-García D, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, Íñiguez-Alvarado MC, García Díaz I, et al. Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life. J Parkinsons Dis. 2023;13(3):379–402.
DS Docusalut
RD 2 oct. 2026