@conference{20.500.13003/20994,
year = {2024},
url = {https://hdl.handle.net/20.500.13003/20994},
abstract = {Introduction: Microplastics (MP) are emerging contaminants
ubiquitously present in the food chain. Increasing evidence
indicates that MP can be absorbed and accumulated
in organs. Plastic additives of MP raise as a major health
concern.
Objective: To analyze the bioavailability and health impact
of polyethylene (PE)-adsorbed bisphenol A (BPA-PE) and
free BPA.
Experimental design: In the study I, rats were gavaged
with 2 mg/kg free BPA, BPA-PE (0.67 g PE/kg), or their respective
vehicles. In the study II, rats were gavaged with
0,67 mg/kg free BPA, BPA-PE (0.22 g PE/kg), pristine PE,
or the combined vehicles. All rats were sacrificed 24 h after
administration.
Results: Plasma glucuronidated BPA (gBPA) was detected
in BPA-PE rats of both studies. In the study I, only free BPA
administration induced (P<0.05) the activity of hepatic antioxidant
proteins (GPx, SOD). Conversely, only BPA-PE administration
altered (P<0.05) the activity of lung antioxidant
enzymes (GRd, SOD). Moreover, only BPA-PE increased
the expression of genes involved in oxidative stress (Mn-
Sod, iNos) in the liver, adipose tissue (AT), and lung; in lung
repair (Tgfb, Col1a1); and in AT lipogenesis (Srepb1c, leptin).
In the study II, gBPA levels from BPA-PE group were
not different from those found in the free BPA group. In the
gut, both free BPA and BPA-PE increased (P<0.05) the activity
of a prooxidant enzyme (MPO), a phase II detoxification
enzyme (GST), and the expression of Mrd1, involved
in the protection from toxics. Both pristine PE and BPA-PE
induced (P<0.05) Tgfb mRNA levels in the lung.
Conclusions: The bioavailability of MP-adsorbed BPA is
similar to that of free BPA. However, the body distribution
of BPA-PE appears to differ from that of free BPA, affecting
organs such as the lung.},
title = {Bioavailability and organ-specific impacts of polyethylene-adsorbed bisphenol A compared to free bisphenol A in rats},
keywords = {Bisphenol A},
keywords = {Microplastics},
keywords = {Bioavailability},
keywords = {Oxidative Stress},
keywords = {Tissue Repair},
author = {Fuster Aparisi, Alberto and Escarrer-Garau, Gabriel and Truyols-Vives, Joan and Garcia Moll, Llucia and Cañete Cánaves, Marc and Estrany Celià, Maria del Mar and Ribas Taberner, Maria Del Mar and Quetglas-Llabrés, Maria Magdalena and González López, Marta and Alayón Afonso, Rafael and Monserrat Mesquida, Margalida and Tejada, Silvia and Ferrer Reynés, Miguel David and Sureda, Antoni and Miró Lladó, Manel and Mercader-Barceló, Josep and Fuster Aparisi, Alberto},
}