%0 Generic
%A Fuster Aparisi, Alberto
%A Escarrer-Garau, Gabriel
%A Truyols-Vives, Joan
%A Garcia Moll, Llucia
%A Cañete Cánaves, Marc
%A Estrany Celià, Maria del Mar
%A Ribas Taberner, Maria Del Mar
%A Quetglas-Llabrés, Maria Magdalena
%A González López, Marta
%A Alayón Afonso, Rafael
%A Monserrat Mesquida, Margalida
%A Tejada, Silvia
%A Ferrer Reynés, Miguel David
%A Sureda, Antoni
%A Miró Lladó, Manel
%A Mercader-Barceló, Josep
%A Fuster Aparisi, Alberto
%T Bioavailability and organ-specific impacts of polyethylene-adsorbed bisphenol A compared to free bisphenol A in rats
%D 2024
%U https://hdl.handle.net/20.500.13003/20994
%X Introduction: Microplastics (MP) are emerging contaminantsubiquitously present in the food chain. Increasing evidenceindicates that MP can be absorbed and accumulatedin organs. Plastic additives of MP raise as a major healthconcern.Objective: To analyze the bioavailability and health impactof polyethylene (PE)-adsorbed bisphenol A (BPA-PE) andfree BPA.Experimental design: In the study I, rats were gavagedwith 2 mg/kg free BPA, BPA-PE (0.67 g PE/kg), or their respectivevehicles. In the study II, rats were gavaged with0,67 mg/kg free BPA, BPA-PE (0.22 g PE/kg), pristine PE,or the combined vehicles. All rats were sacrificed 24 h afteradministration.Results: Plasma glucuronidated BPA (gBPA) was detectedin BPA-PE rats of both studies. In the study I, only free BPAadministration induced (P<0.05) the activity of hepatic antioxidantproteins (GPx, SOD). Conversely, only BPA-PE administrationaltered (P<0.05) the activity of lung antioxidantenzymes (GRd, SOD). Moreover, only BPA-PE increasedthe expression of genes involved in oxidative stress (Mn-Sod, iNos) in the liver, adipose tissue (AT), and lung; in lungrepair (Tgfb, Col1a1); and in AT lipogenesis (Srepb1c, leptin).In the study II, gBPA levels from BPA-PE group werenot different from those found in the free BPA group. In thegut, both free BPA and BPA-PE increased (P<0.05) the activityof a prooxidant enzyme (MPO), a phase II detoxificationenzyme (GST), and the expression of Mrd1, involvedin the protection from toxics. Both pristine PE and BPA-PEinduced (P<0.05) Tgfb mRNA levels in the lung.Conclusions: The bioavailability of MP-adsorbed BPA issimilar to that of free BPA. However, the body distributionof BPA-PE appears to differ from that of free BPA, affectingorgans such as the lung.
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