RT Conference Proceedings
T1 Bioavailability and organ-specific impacts of polyethylene-adsorbed bisphenol A compared to free bisphenol A in rats
A1 Fuster Aparisi, Alberto
A1 Escarrer-Garau, Gabriel
A1 Truyols-Vives, Joan
A1 Garcia Moll, Llucia
A1 Cañete Cánaves, Marc
A1 Estrany Celià, Maria del Mar
A1 Ribas Taberner, Maria Del Mar
A1 Quetglas-Llabrés, Maria Magdalena
A1 González López, Marta
A1 Alayón Afonso, Rafael
A1 Monserrat Mesquida, Margalida
A1 Tejada, Silvia
A1 Ferrer Reynés, Miguel David
A1 Sureda, Antoni
A1 Miró Lladó, Manel
A1 Mercader-Barceló, Josep
A1 Fuster Aparisi, Alberto
AB Introduction: Microplastics (MP) are emerging contaminantsubiquitously present in the food chain. Increasing evidenceindicates that MP can be absorbed and accumulatedin organs. Plastic additives of MP raise as a major healthconcern.Objective: To analyze the bioavailability and health impactof polyethylene (PE)-adsorbed bisphenol A (BPA-PE) andfree BPA.Experimental design: In the study I, rats were gavagedwith 2 mg/kg free BPA, BPA-PE (0.67 g PE/kg), or their respectivevehicles. In the study II, rats were gavaged with0,67 mg/kg free BPA, BPA-PE (0.22 g PE/kg), pristine PE,or the combined vehicles. All rats were sacrificed 24 h afteradministration.Results: Plasma glucuronidated BPA (gBPA) was detectedin BPA-PE rats of both studies. In the study I, only free BPAadministration induced (P<0.05) the activity of hepatic antioxidantproteins (GPx, SOD). Conversely, only BPA-PE administrationaltered (P<0.05) the activity of lung antioxidantenzymes (GRd, SOD). Moreover, only BPA-PE increasedthe expression of genes involved in oxidative stress (Mn-Sod, iNos) in the liver, adipose tissue (AT), and lung; in lungrepair (Tgfb, Col1a1); and in AT lipogenesis (Srepb1c, leptin).In the study II, gBPA levels from BPA-PE group werenot different from those found in the free BPA group. In thegut, both free BPA and BPA-PE increased (P<0.05) the activityof a prooxidant enzyme (MPO), a phase II detoxificationenzyme (GST), and the expression of Mrd1, involvedin the protection from toxics. Both pristine PE and BPA-PEinduced (P<0.05) Tgfb mRNA levels in the lung.Conclusions: The bioavailability of MP-adsorbed BPA issimilar to that of free BPA. However, the body distributionof BPA-PE appears to differ from that of free BPA, affectingorgans such as the lung.
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.13003/20994
UL https://hdl.handle.net/20.500.13003/20994
LA eng
NO Fuster Aparisi A, Escarrer Garau G, Truyols Vives J, Garcia Moll L, Cañete Cánaves M, Estrany Celià MM, Ribas MM, Quetglas Llabrés MM, González López M, Jiménez García M, Alayón Afonso R, Monserrat Mesquida M, Tejada Gavela S, Ferrer Reynés MD, Sureda Gomila A, Miró Lladó M, Mercader Barceló J. Bioavailability and organ-specific impacts of polyethylene-adsorbed bisphenol A compared to free bisphenol A in rats. Poster presented at XLII Reunión anual de la Sociedad Española de Epidemiología (SEE); 10-13 de september 2024; Cádiz.
DS Docusalut
RD 5 jul. 2026