@article{20.500.13003/21388,
year = {2024},
month = {11},
url = {https://hdl.handle.net/20.500.13003/21388},
abstract = {To evaluate the influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism (PA).
Multicenter retrospective study of patients with PA in 36 Spanish tertiary hospitals with available information on smoking habits (smokers and non-smokers [never smokers and ex-smokers]).
A total of 881 patients were included, of whom 180 (20.4%) were classified as smokers and 701 as non-smokers. At diagnosis, smokers and non-smokers did not differ in blood pressure or serum potassium levels between. However, smokers had a higher prevalence of left ventricular hypertrophy (LVH) than non-smokers (OR 2.0, 95% CI 1.23 to 3.25), and smokers were more likely to have severe LVH than non-smokers (12.5% vs. 6.6%, P=0.164). A larger mean tumor size of the adrenal nodule/s was observed in the smoking group (18.6±9.66 vs. 15.8±8.66 mm, P=0.002). In addition, the odds of mild autonomous cortisol secretion (MACS) was greater in smokers than in non-smokers (OR 2.1, 95% CI 1.14 to 4.06), but these differences disappeared when adjusted for the size of the adrenal nodule/s (adjusted OR 1.6, 95% CI 0.76 to 3.37). The rate of biochemical and hypertension cure was similar in both groups; however, hypertension cure tended to be more frequent in the non-smoker group (41.2% vs 29.9%, P=0.076).
Patients with PA who smoke have a higher prevalence of LVH and MACS and larger adrenal nodule/s than non-smokers. Smoking has no significant effect on the probability of hypertension response after adrenalectomy in patients with PA.},
publisher = {Oxford},
title = {Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism. A cohort study},
doi = {10.1093/ejendo/lvae143},
journal = {European journal of endocrinology},
author = {Araujo-Castro, Marta and Paja Fano, Miguel and González-Boillos, Marga and Pascual-Corrales, Eider and Parra Ramírez, Paola and Martín Rojas-Marcos, Patricia  and García-Cano, Ana and Ruiz-Sanchez, Jorge Gabriel and Vicente, Almudena and Gómez-Hoyos, Emilia and Casterás, Ana and Puig-Perez, Albert and García Sanz, Iñigo and Recasens, Mònica and Barahona San Millan, Rebeca and Picón César, María José and Diaz Guardiola, Patricia and Perdomo, Carolina and Manjón-Miguélez, Laura and Rebollo Román, Ángel and Robles Lázaro, Cristina and Recio, José María and Morales-Ruiz, Manuel and Calatayud, María and Jiménez López, Noemi and Meneses, Diego and Sampedro Nuñez, Miguel and Mena Ribas, Elena and Sanmartín-Sánchez, Alicia and Gonzalvo Diaz, Cesar  and Lamas, Cristina and Del Castillo Tous, María and Serrano, Joaquín and Michalopoulou, Theodora and Tenes Rodrigo, Susana  and Roa Chamorro, Ricardo  and Jaén Aguila, Fernando  and Moya Mateo, Eva María and Gutiérrez-Medina, Sonsoles and Hanzu, Felicia Alexandra},
}