RT Journal Article
T1 Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism. A cohort study
A1 Araujo-Castro, Marta
A1 Paja Fano, Miguel
A1 González-Boillos, Marga
A1 Pascual-Corrales, Eider
A1 Parra Ramírez, Paola
A1 Martín Rojas-Marcos, Patricia
A1 García-Cano, Ana
A1 Ruiz-Sanchez, Jorge Gabriel
A1 Vicente, Almudena
A1 Gómez-Hoyos, Emilia
A1 Casterás, Ana
A1 Puig-Perez, Albert
A1 García Sanz, Iñigo
A1 Recasens, Mònica
A1 Barahona San Millan, Rebeca
A1 Picón César, María José
A1 Diaz Guardiola, Patricia
A1 Perdomo, Carolina
A1 Manjón-Miguélez, Laura
A1 Rebollo Román, Ángel
A1 Robles Lázaro, Cristina
A1 Recio, José María
A1 Morales-Ruiz, Manuel
A1 Calatayud, María
A1 Jiménez López, Noemi
A1 Meneses, Diego
A1 Sampedro Nuñez, Miguel
A1 Mena Ribas, Elena
A1 Sanmartín-Sánchez, Alicia
A1 Gonzalvo Diaz, Cesar
A1 Lamas, Cristina
A1 Del Castillo Tous, María
A1 Serrano, Joaquín
A1 Michalopoulou, Theodora
A1 Tenes Rodrigo, Susana
A1 Roa Chamorro, Ricardo
A1 Jaén Aguila, Fernando
A1 Moya Mateo, Eva María
A1 Gutiérrez-Medina, Sonsoles
A1 Hanzu, Felicia Alexandra
AB To evaluate the influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism (PA).Multicenter retrospective study of patients with PA in 36 Spanish tertiary hospitals with available information on smoking habits (smokers and non-smokers [never smokers and ex-smokers]).A total of 881 patients were included, of whom 180 (20.4%) were classified as smokers and 701 as non-smokers. At diagnosis, smokers and non-smokers did not differ in blood pressure or serum potassium levels between. However, smokers had a higher prevalence of left ventricular hypertrophy (LVH) than non-smokers (OR 2.0, 95% CI 1.23 to 3.25), and smokers were more likely to have severe LVH than non-smokers (12.5% vs. 6.6%, P=0.164). A larger mean tumor size of the adrenal nodule/s was observed in the smoking group (18.6±9.66 vs. 15.8±8.66 mm, P=0.002). In addition, the odds of mild autonomous cortisol secretion (MACS) was greater in smokers than in non-smokers (OR 2.1, 95% CI 1.14 to 4.06), but these differences disappeared when adjusted for the size of the adrenal nodule/s (adjusted OR 1.6, 95% CI 0.76 to 3.37). The rate of biochemical and hypertension cure was similar in both groups; however, hypertension cure tended to be more frequent in the non-smoker group (41.2% vs 29.9%, P=0.076).Patients with PA who smoke have a higher prevalence of LVH and MACS and larger adrenal nodule/s than non-smokers. Smoking has no significant effect on the probability of hypertension response after adrenalectomy in patients with PA.
PB Oxford
YR 2024
FD 2024-11-18
LK https://hdl.handle.net/20.500.13003/21388
UL https://hdl.handle.net/20.500.13003/21388
LA eng
NO Araujo-Castro M, Paja Fano M, González-Boillos M, Pascual-Corrales E, Parra Ramírez P, Rojas-Marcos PM, et al. Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism. A cohort study. Eur J Endocrinol. 2024 Nov 18.
DS Docusalut
RD 16 jun. 2026