RT Journal Article
T1 Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients
A1 Carrillo-García, Jaime
A1 Lacerenza, Serena
A1 Hindi, Nadia
A1 Moura, David S
A1 Marquina, Gloria
A1 Parra Corral, Daniel
A1 Olalla, Jennifer
A1 María Cano Cano, Juana
A1 Hoyos, Sergio
A1 Renshaw, Marta
A1 Mondaza-Hernández, Jose L
A1 Di Lernia, Davide
A1 Casado, Antonio
A1 Manzano, Arantxa
A1 Gutiérrez, Antonio
A1 Martin-Broto, Javier
AB The COVID-19 patients showed hyperinflammatory response depending on the severity of the disease but little have been reported about this response in oncologic patients that also were infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sixty-five circulating cytokines/chemokines were quantified in 15 oncologic patients, just after SARS-CoV-2 infection and fourteen days later, and their levels were compared in patients who required hospitalisation by COVID-19 versus non-hospitalised patients. A higher median age of 72 years (range 61-83) in oncologic patients after SARS-CoV-2 infection was associated with hospitalisation requirement by COVID-19 versus a median age of 49 years (20-75) observed in the non-hospitalised oncologic patients (p = 0.008). Moreover, oncologic patients at metastatic stage or with lung cancer were significantly associated with hospitalisation by COVID-19 (p = 0.044). None of these hospitalised patients required ICU treatment. Higher basal levels of tumour necrosis factor receptor II (TNF-RII), interferon-γ (IFNγ)-induced protein 10 (IP-10) and hepatocyte growth factor (HGF) in plasma were significantly observed in oncologic patients who required hospitalisation by COVID-19. Higher TNF-RII, IP-10 and HGF levels after the SARS-CoV-2 infection in oncologic patients could be used as biomarkers of COVID-19 severity associated with hospitalisation requirements.
PB Elsevier
YR 2024
FD 2024-05
LK https://hdl.handle.net/20.500.13003/20253
UL https://hdl.handle.net/20.500.13003/20253
LA eng
NO Carrillo-García J, Lacerenza S, Hindi N, Moura DS, Marquina G, Parra Corral D, et al. Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients. Cytokine. 2024 Feb 15;177:156542.
DS Docusalut
RD 14 may. 2026