RT Journal Article T1 The impact of exposure to tobacco smoke and e-cigarettes on asthma-related outcomes: Systematic review informing the EAACI guidelines on environmental science for allergic diseases and asthma A1 Agache, Ioana A1 Ricci-Cabello, Ignacio A1 Canelo-Aybar, Carlos A1 Annesi-Maesano, Isabella A1 Cecchi, Lorenzo A1 Biagioni, Benedetta A1 Chung, Kian Fan A1 D'Amato, Gennaro A1 Damialis, Athanasios A1 Del Giacco, Stefano A1 De Las Vecillas, Leticia A1 Domínguez-Ortega, Javier A1 Galán, Carmen A1 Gilles, Stefanie A1 Giovannini, Matteo A1 Holgate, Stephen A1 Jeebhay, Mohamed A1 Nadeau, Kari A1 Papadopoulos, Nikolaos G A1 Quirce, Santiago A1 Sastre, Joaquin A1 Traidl-Hoffmann, Claudia A1 Walusiak-Skorupa, Jolanta A1 Salazar, Josefina A1 Sousa-Pinto, Bernardo A1 Colom, Miquel A1 Fiol-deRoque, Maria Antonia A1 Gorreto López, Lucía A1 Malih, Narges A1 Moro, Laura A1 Garcia Pardo, Marina A1 García-Pazo, Patricia A1 Zamanillo Campos, Rocío A1 Saletti-Cuesta, L A1 Akdis, Mubeccel A1 Alonso-Coello, Pablo A1 Jutel, Marek A1 Akdis, Cezmi A AB To inform the clinical practice guidelines' recommendations developed by the European Academy of Allergy and Clinical Immunology systematic reviews (SR) assessed using GRADE on the impact of environmental tobacco smoke (ETS) and active smoking on the risk of new-onset asthma/recurrent wheezing (RW)/low lung function (LF), and on asthma-related outcomes. Only longitudinal studies were included, almost all on combustion cigarettes, only one assessing e-cigarettes and LF. According to the first SR (67 studies), prenatal ETS increases the risk of RW (moderate certainty evidence) and may increase the risk of new-onset asthma and of low LF (low certainty evidence). Postnatal ETS increases the risk of new-onset asthma and of RW (moderate certainty evidence) and may impact LF (low certainty evidence). Combined in utero and postnatal ETS may increase the risk of new-onset asthma (low certainty evidence) and increases the risk of RW (moderate certainty evidence). According to the second SR (24 studies), ETS increases the risk of severe asthma exacerbations and impairs asthma control and LF (moderate certainty evidence). According to the third SR (25 studies), active smoking increases the risk of severe asthma exacerbations and of suboptimal asthma control (moderate certainty evidence) and may impact asthma-related quality-of-life and LF (low certainty evidence). PB Wiley YR 2024 FD 2024-05-23 LK https://hdl.handle.net/20.500.13003/20372 UL https://hdl.handle.net/20.500.13003/20372 LA eng NO Agache I, Ricci‐Cabello I, Canelo‐Aybar C, Annesi‐Maesano I, Cecchi L, Biagioni B, et al. The impact of exposure to tobacco smoke and e‐cigarettes on asthma‐related outcomes: Systematic review informing the EAACI guidelines on environmental science for allergic diseases and asthma. Allergy. 2024 May 23; NO This is an postprint (Accepted Manuscript) of an article published by Wiley in Allergy on 23 May, available online: https://doi.org/10.1111/all.16151 DS Docusalut RD 21 jul. 2026