%0 Journal Article
%A Martín-Peláez, Sandra
%A Serra-Majem, Lluis
%A Cano-Ibáñez, Naomi
%A Martínez-González, Miguel Ángel
%A Salas-Salvado, Jordi
%A Corella, Dolores
%A Lassale, Camille
%A Martínez, Jose Alfredo
%A Alonso-Gomez, Angel M.
%A Wärnberg, Julia
%A Vioque, Jesus
%A Romaguera, Dora
%A López-Miranda, José
%A Estruch, Ramon
%A Tinahones, Francisco J
%A Lapetra, José
%A Fernández-Aranda, Fernando
%A Bueno-Cavanillas, Aurora
%A Tur, Josep A.
%A Martín, Vicente
%A Pintó, Xavier
%A Delgado-Rodriguez, Miguel
%A Matía, Pilar
%A Vidal, Josep
%A Vazquez, Clotilde
%A Daimiel, Lidia
%A Ros, Emilio
%A Toledo, Estefanía
%A Nishi, Stephanie K
%A Sorli, Jose V.
%A Malcampo, Mireia
%A Zulet, M. Angeles
%A Moreno-Rodríguez, Anaí
%A Cueto-Galán, Raquel
%A Vivancos-Aparicio, Diego
%A Colom Fernández, Antoni
%A García-Ríos, Antonio
%A Casas, Rosa
%A Rosa Bernal-Lopez, Maria
%A Santos-Lozano, José Manuel
%A Vázquez, Zenaida
%A Gómez-Martínez, Carlos
%A Ortega-Azorín, Carolina
%A Del Val García, Jose Luís
%A Abete, Itziar
%A Goikoetxea-Bahon, Amaia
%A Pascual, Elena
%A Becerra-Tomas, Nerea
%A Chillarón, Juan J
%A Sanchez-Villegas, Almudena
%T Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
%D 2022
%U https://hdl.handle.net/20.500.13003/18032
%X Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial.Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively).Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
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