RT Journal Article
T1 Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
A1 Martín-Peláez, Sandra
A1 Serra-Majem, Lluis
A1 Cano-Ibáñez, Naomi
A1 Martínez-González, Miguel Ángel
A1 Salas-Salvado, Jordi
A1 Corella, Dolores
A1 Lassale, Camille
A1 Martínez, Jose Alfredo
A1 Alonso-Gomez, Angel M.
A1 Wärnberg, Julia
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 López-Miranda, José
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, José
A1 Fernández-Aranda, Fernando
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A.
A1 Martín, Vicente
A1 Pintó, Xavier
A1 Delgado-Rodriguez, Miguel
A1 Matía, Pilar
A1 Vidal, Josep
A1 Vazquez, Clotilde
A1 Daimiel, Lidia
A1 Ros, Emilio
A1 Toledo, Estefanía
A1 Nishi, Stephanie K
A1 Sorli, Jose V.
A1 Malcampo, Mireia
A1 Zulet, M. Angeles
A1 Moreno-Rodríguez, Anaí
A1 Cueto-Galán, Raquel
A1 Vivancos-Aparicio, Diego
A1 Colom Fernández, Antoni
A1 García-Ríos, Antonio
A1 Casas, Rosa
A1 Rosa Bernal-Lopez, Maria
A1 Santos-Lozano, José Manuel
A1 Vázquez, Zenaida
A1 Gómez-Martínez, Carlos
A1 Ortega-Azorín, Carolina
A1 Del Val García, Jose Luís
A1 Abete, Itziar
A1 Goikoetxea-Bahon, Amaia
A1 Pascual, Elena
A1 Becerra-Tomas, Nerea
A1 Chillarón, Juan J
A1 Sanchez-Villegas, Almudena
AB Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial.Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively).Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
PB Plos One
YR 2022
FD 2022-04-13
LK https://hdl.handle.net/20.500.13003/18032
UL https://hdl.handle.net/20.500.13003/18032
LA eng
NO Martín-Peláez S, Serra-Majem L, Cano-Ibáñez N, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. Lim L-L, editor. PLoS One. 2022 Apr 13;17(4):e0265079.
DS Docusalut
RD 22 ago. 2026