Rubí, SebastiàBibiloni, PedroVillar, MarinaBrell Doval, MartaValiente, ManuelGalmés, MargalidaToscano, MaríaMatheu, GabrielChinchilla, José LuisMolina Pardos, JesúsValera Felices, Jose LuisRíos Olivencia, ÁngelLópez, MeritxellPeña, Cristina2024-07-022024-07-022024Rubí S, Bibiloni P, Villar M, Brell M, Valiente M, Galmés M, et al. Full kinetic modeling analysis of [18F]fluorocholine Positron Emission Tomography (PET) at initial diagnosis of high-grade glioma. NeuroImage Clin. 2024;42:103616.https://hdl.handle.net/20.500.13003/20528The main objective was to characterize the tracer uptake kinetics of [18F]fluoromethylcholine ([18F]F-CHO) in high-grade gliomas (HGG) through a full PET kinetic modeling approach. Secondarily, we aimed to explore the relationship between the PET uptake measures and the HGG molecular features. Twenty-four patients with a suspected diagnosis of HGG were prospectively included. They underwent a dynamic brain [18F]F-CHO-PET/CT, from which a tumoral time-activity curve was extracted. The plasma input function was obtained through arterial blood sampling with metabolite correction. These data were fitted to 1- and 2-tissue-compartment models, the best of which was selected through the Akaike information criterion. We assessed the correlation between the kinetic parameters and the conventional static PET metrics (SUVmax, SUVmean and tumor-to-background ratio TBR). We explored the association between the [18F]F-CHO-PET quantitative parameters and relevant molecular biomarkers in HGG. Tumoral time-activity curves in all patients showed a rapid rise of [18F]F-CHO uptake followed by a plateau-like shape. Best fits were obtained with near-irreversible 2-tissue-compartment models. The perfusion-transport constant K1 and the net influx rate Ki showed strong correlation with SUVmax (r = 0.808-0.861), SUVmean (r = 0.794-0.851) and TBR (r = 0.643-0.784), p < 0.002. HGG was confirmed in 21 patients, of which those with methylation of the O-6-methylguanine-DNA methyltransferase (MGMT) gene promoter showed higher mean Ki (p = 0.020), K1 (p = 0.025) and TBR (p = 0.001) than the unmethylated ones. [18F]F-CHO uptake kinetics in HGG is best explained by a 2-tissue-compartment model. The conventional static [18F]F-CHO-PET measures have been validated against the perfusion-transport constant (K1) and the net influx rate (Ki) derived from kinetic modeling. A relationship between [18F]F-CHO uptake rate and MGMT methylation is suggested but needs further confirmation.engAtribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/Brain NeoplasmsRadiopharmaceuticalsAgedPositron-Emission TomographyAdultCholineHumansGliomaKineticsMiddle AgedNeoplasm GradingMalePositron Emission Tomography Computed TomographyProspective StudiesFemaleresearch articleTomografía Computarizada por Tomografía de Emisión de PositronesFemeninoClasificación del TumorMasculinoTomografía de Emisión de PositronesColinaGliomaHumanosPersona de Mediana EdadEstudios ProspectivosCinéticaAncianoRadiofármacosNeoplasias EncefálicasAdultoGliomaCholineBrain NeoplasmsHumansMiddle AgedMaleFemaleAdultAgedPositron-Emission TomographyKineticsPositron Emission Tomography Computed TomographyRadiopharmaceuticalsProspective StudiesNeoplasm Grading10.1016/j.nicl.2024.1036162213-158238763039L20323211462-s2.0-85193450253001245193800001open access