Carrillo-García, JaimeLacerenza, SerenaHindi, NadiaMoura, David SMarquina, GloriaParra Corral, DanielOlalla, JenniferMaría Cano Cano, JuanaHoyos, SergioRenshaw, MartaMondaza-Hernández, Jose LDi Lernia, DavideCasado, AntonioManzano, ArantxaGutiérrez, AntonioMartin-Broto, Javier2024-03-122024-03-122024-05Carrillo-García J, Lacerenza S, Hindi N, Moura DS, Marquina G, Parra Corral D, et al. Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients. Cytokine. 2024 Feb 15;177:156542.https://hdl.handle.net/20.500.13003/20253The COVID-19 patients showed hyperinflammatory response depending on the severity of the disease but little have been reported about this response in oncologic patients that also were infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sixty-five circulating cytokines/chemokines were quantified in 15 oncologic patients, just after SARS-CoV-2 infection and fourteen days later, and their levels were compared in patients who required hospitalisation by COVID-19 versus non-hospitalised patients. A higher median age of 72 years (range 61-83) in oncologic patients after SARS-CoV-2 infection was associated with hospitalisation requirement by COVID-19 versus a median age of 49 years (20-75) observed in the non-hospitalised oncologic patients (p = 0.008). Moreover, oncologic patients at metastatic stage or with lung cancer were significantly associated with hospitalisation by COVID-19 (p = 0.044). None of these hospitalised patients required ICU treatment. Higher basal levels of tumour necrosis factor receptor II (TNF-RII), interferon-γ (IFNγ)-induced protein 10 (IP-10) and hepatocyte growth factor (HGF) in plasma were significantly observed in oncologic patients who required hospitalisation by COVID-19. Higher TNF-RII, IP-10 and HGF levels after the SARS-CoV-2 infection in oncologic patients could be used as biomarkers of COVID-19 severity associated with hospitalisation requirements.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/AgedAged, 80 and overCOVID-19* / diagnosisCOVID-19* / metabolismChemokine CXCL10 / bloodChemokine CXCL10 / chemistryHepatocyte Growth Factor / bloodHepatocyte Growth Factor / chemistryHumansMiddle AgedNeoplasms* / metabolismReceptors, Tumor Necrosis Factor, Type II / bloodReceptors, Tumor Necrosis Factor, Type II / chemistrySARS-CoV-2research articleAncianoHumanosPersona de Mediana EdadSARS-CoV-210.1016/j.cyto.2024.1565421096-002338364458L20304567142-s2.0-85185338942001186375600001open access